CNS
Depressant Drug
Cannabis plan
Origin: dried
flowering or fruiting tops of pistillate plant of cannabis sativa family
cannabinaceae
·
Female plant: has
thread like style with mushroom like glandular hair.
·
Male plant: has oval
pollen sac &contain low % of cannabinoids than female &used for twin
fibers.
About 500 compounds are
separated from cannabis plant but only 86
compounds are cannabinoids.
Cannabinoids: they are group of (c21) typically
and present in cannabis sativa, and their carboxyllic and their transformed
products.
Cannabinoids belongs to class of terpenophenols,
dibenzopyran with n-pentyl side chain
Cannabinoids of forensic signficans:
·
Tetrahydro cannabinol
(THC): responsible for most activity of normal (old fashion)
cannabis and has viscous oil properties
·
Cannabinol (CBN) : it
is dibenzopyran compound, solid compound.
·
Cannabidiol (CBD) : diphenolic compound,no psyco-activity
and used for treatment of myosclerosis.
Pharmacological effect :
·
It cause mild
hallucination followed by CNS Depression (sedative, hypnotic) and
deterioration of muscle co-ordination (ataxia).
Medicinal uses:
·
Cannabis was used as sedative, analgesic and for treatment of obesity.
·
Terahydro cannabinol (THC) is used as anti-emetic drug.
·
Dronabinol, marinol andnabilone are synthetic (THC) products used as
anti-emetic drugs in patient receiving cancer chemotherapy.
·
Terahydro cannabinol (THC) is used as appetite stimulant in patients of HIV.
